For the whole nature of man became guilty in the person of him who was first formed; but now it is wholly justified again in Christ. -- St. Cyril of Alexandria, Homily 42 on St. Luke
And so the human race was lying under a just condemnation, and all men were the children of wrath. Of which wrath it is written: "All our days are passed away in Your wrath; we spend our years as a tale that is told." Of which wrath also Job says: "Man that is born of a woman is of few days, and full of trouble." Of which wrath also the Lord Jesus says: "He that believes in the Son has everlasting life: and he that believes not the Son shall not see life; but the wrath of God abides on him." He does not say it will come, but it "abides on him." For every man is born with it; wherefore the apostle says: "We were by nature the children of wrath, even as others." Now, as men were lying under this wrath by reason of their original sin, and as this original sin was the more heavy and deadly in proportion to the number and magnitude of the actual sins which were added to it, there was need for a Mediator, that is, for a reconciler, who, by the offering of one sacrifice, of which all the sacrifices of the law and the prophets were types, should take away this wrath. Wherefore the apostle says: "For if, when we were enemies, we were reconciled to God by the death of His Son, much more, being reconciled, we shall be saved by His life." Now when God is said to be angry, we do not attribute to Him such a disturbed feeling as exists in the mind of an angry man; but we call His just displeasure against sin by the name "anger," a word transferred by analogy from human emotions. But our being reconciled to God through a Mediator, and receiving the Holy Spirit, so that we who were enemies are made sons ("For as many as are led by the Spirit of God, they are the sons of God"): this is the grace of God through Jesus Christ our Lord. – St. Augustine, Enchiridion 33
“The psalmist does not suppose that he is living this life, for he had said, See, I was conceived in iniquities and my mother bore me in sins. He know that he was born from a sinful origin and under the law of sin.” - St. Hilary (Commentary on Psalm 118, 22)
“The words ‘the Jordan turned backward’ (Ps 114:3), signified the future mysteries of the bath of salvation through which the little ones who have been baptized are changed from wickedness back to their original state.” - St. Ambrose (Commentary on Luke 1, 37)
"We then say, that in many things we all of us offend, and that no man is pure from uncleanness, even though his life upon earth be but one day. Let us ask then of God mercy; which if we do, Christ will justify us; by Whom and with Whom, to God the Father, be praise and dominion, with the Holy Spirit, unto ages of ages. Amen." - Homily 120 on Luke 18 - St. Cyril of Alexandria
And if you like to hear what other saints also have felt in regard to physical birth, listen to David when he says, I was conceived, so it runs, in iniquity and in sin my mother hath borne me, proving that every soul which is born in the flesh is tainted with the stain of iniquity and sin. This is the reason for that saying which we have already quoted above, No man is clean from sin, not even if his life be one day long. To these, as a further point, may be added an enquiry into the reason for which, while the church's baptism is given for the remission of sin, it is the custom of the church that baptism be administered even to infants. Certainly, if there were nothing in infants that required remission and called for lenient treatment, the grace of baptism would seem unnecessary. (R.B. Tollinton, Selections From The Commentaries And Homilies of Origen, 1929, p. 211)
Brethren, the selection (rom 5:12-14) from the Apostle for today tells us that through one man the whole world received its sentence… The downfall of one man has flowed out to become a punishment of all, and the vice of the parent has brought a sad catastrophe upon the whole race. (Chrysologus, Sermon 111, Original Sin, p. 175 vol. 17 FOTC)
Through a man sin came and clearly through this sin we are seen to have come under the control of death. O sin, you cruel beast – and a beast not content to vent your fury against the human race from merely one head. We have seen this beast, brethren, devouring with a triple head all the highly precious sprouts of the human family. Yes, brethren, with a mouth that is triple: as sin this beast captures, as death it devours, as hell it swallows down. (ibid, p. 176, 177)